Patients after laparoscopic liver surgery Nefopam, Laparoscopic liver surgery, Postoperative pain, Opioid consumption
Conditions
Interventions
20 mg of nefopam diluted in 0.9%NSS up to 100 ml IV drip in 30 minutes at the end of surgery and then 60 mg of nefopam diluted in 0.9%NSS up to 500 ml IV continuous for 24 hours,receiving placebo as i
Active Comparator Drug,Placebo Comparator No treatment
Sponsors
Khon Kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old 2. Patient who undergoing laparoscopic liver surgery 3. ASA classification I-III
Exclusion criteria
Exclusion criteria: 1. Severe systemic medical condition such as poor-controlled hypertension, heart disease, lung disease, renal dysfunction with GFR less than 60, poor-controlled diabetes mellitus, Child-Pugh class B or C, Abnormal liver function test (total bilirubin > 2 mg/dL, INR > 1.7, albumin < 3,5 g/dL, or aspartate or alanine aminotransferase > 2 times of upper limit of normal), neuromuscular disease 2. Chronic pain problem 3. Prescribed analgesic drugs 4. Contraindication to nefopam such as tachyarrhythmia, pregnancy, convulsive disorder, taking monoamine oxidase inhibitors 5. Allergic to study drugs 6. Unable or refusal to use IV PCA 7. Unable to understand and report numeric rating pain score 8. Anesthetic care personnel plan to do neuraxial or trunk blocks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative morphine consumption in 24 hours At 24 hours postoperatively Data from IV PCA machine | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score At 0, 1, 6, 12, 24, 48 hours postoperatively Numeric rating scale,Incidence of adverse effects During 24 hours postoperatively Dry mouth, profuse sweating, nausea, and vomiting | — |
Countries
Thailand
Contacts
Public ContactPeerapong Sangsungnern
Faculty of Medicine, Khon Kaen University
Outcome results
None listed