Healthy condition functional drink cognitive function mood working-age volunteers
Conditions
Interventions
Subjects received the placebo product which has the same color and smell and looks like the functional drink.,Subjects received the functional drink contained 36.6% guava juice &
mint syrup.,Subjects received the functional drink contained 73.2% guava juice &
mint syrup.
Placebo,Low dose of the functional drink,High dose of the functional drink
Sponsors
Research Institute for Human High Performance and Health Promotion (HHP&HP)
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Healthy, working-aged, volunteers between the ages of 20 and 40 year 2. BMI 18.5-25 kg/m2 3. All volunteers did not consume tea, coffee, chocolate, and alcohol for at least 12 hours before as well as during the trial.
Exclusion criteria
Exclusion criteria: 1. Participants are undergoing treatment with any medication or consuming any herbal products that may have an impact on the nervous system function during the trial and within 3 months prior to the beginning of the trial, 2. Participants had a previous diagnosis or history of cancer, diabetes, cardiovascular, respiratory, gastrointestinal disease, traumatic brain injury, nervous system or psychiatric disorders, or allergies, 3. Individuals have moderate severe anxiety or moderate severe depression or HADS more 11, 4. Participants are pregnant or breastfeeding before and during the trial, 5. Individuals smoked more 10 cigarettes per day as well as had difficulties refraining from smoking during the trial, 6. Participants consumed probiotics 3 months prior to and during the trial, 7. Participants consumed antibiotics in the 1 week prior to the trial, 8. Participants who exercised more than three times each week, 9. Do not follow the requirements of the study while attending the trial, 10. Participants reported positive auditory responses at sensible sound intensities of less than 16 dB
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive enhancing effects 2 months measured Event-Related Potentials (ERPs) | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurotransmitters in serum: MAO, MAO-A, MAO-B, GABA-T, GAD, AChE 2 months laboratory,Proinflammatory IL-1beta TNF-alpha IL6 2 months laboratory,Brain-derived neurotrophic factor (BDNF) and cortisol level in serum 2 months laboratory,Levels of SCFA, lactate, Lactobacillus spp. and Bifidobacterium spp. in feces 2 months laboratory,The changes of hematological and clinical chemistry parameters 2 months laboratory,Phenolic compounds and flavonoids content in serum 2 months laboratory | — |
Countries
Thailand
Contacts
Public ContactHai Ha Nguyen
Faculty of Medicine, Khon Kaen University
Outcome results
None listed