Healthy condition Functional drink Dietary fiber Stress index Working age
Conditions
Interventions
Subjects received the placebo product which has the same color and smell and looks like the functional drink containing dietary fiber 3g per day but without bean and mulberry fruit.,Subjects received
Placebo, the functional drink containing bean and mulberry fruit 3 g per day plus dietary fiber 3 g per day, the functional drink containing bean and mulberry fruit 6 g per day plus dietary fiber 3 g
Sponsors
Research Institute for Human High Performance and Health Promotion (HHP&HP)
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male or Female Aged between 30-60 years old 2. Body Mass Index (BMI) 18-25 kg/m2 3. DASS-21 indicate stress or anxiety 4. Can read and write Thai language
Exclusion criteria
Exclusion criteria: 1. Volunteers who have been diagnosed with one of the following; heart disease, lung disease or allergies, diabetes, high blood pressure, liver disease, kidney disease, head injury, and mental disorder. 2. Volunteers who use antibiotics in the last one week before study. 3. Volunteers who use supplement contain probiotics in the last three months before study. 4. Volunteers who have been Hysterectomy and/or Oophorectomy. 5. Volunteers who use hormone or any drug that effect on on the nervous system, Hypothalamic Pituitary Gonadal axis, Hypothalamic Pituitary Adrenal, and Hypothalamic Pituitary Thyroid axis. 6. Volunteers who use antibiotics immunosuppressant in the last 1 week before the study 7. Use of food supplement contain probiotics/prebiotics/dietary fibers more 3 times/week 8. Drinking alcohol more than 5 times per day 9. Smoking more than 10 pieces per day 10. Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression Anxiety and Stress Scale - 21 (DASS-21) 2 months questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress index changes of CRH,cortisol, amylase, level 2 months laboratory,Thai GHQ28 2 months questionnaire,The changes of hematological and clinical chemistry parameters 2 months laboratory,Evaluation of Neurotransmitters; Acetylcholinesterase (AChE), Total Monoamine oxidase (MAO), MAO-A, and glutamic acid decarboxylase (GAD) 2 months laboratory,The changes of Electrocardiogram 2 months Electrocardiography,Stool examination; PH, Lactobacillus spp., Bifidobacterium spp., and Short chain fatty acid 2 months laboratory,Thai-PSQI questionnaires 2 months questionnaire,Neurodegeneration (Homocysteine (Hcy), Brain derived growth factor (BDNF), IL-10 2 months laboratory,Immune response; population of NK-cell, T-cells in PBMCs 2 months laboratory | — |
Countries
Thailand
Contacts
Public ContactPontapan Polyiam
Faculty of Medicine, Khon Kaen University
Outcome results
None listed