Healthy human volunteers Drug absorption Fractional Erbium yag Steroid
Conditions
Interventions
The researcher will randomly select the side of the arm to be applied with triamcinolone acetonide solution and to be applied with triamcinolone acetonide cream. On the triamcinolone acetonide solutio
Sham Comparator Device,Active Comparator Drug,Experimental Drug,Sham Comparator Device,Active Comparator Drug,Experimental Drug
Laser alone (on TA solution arm),Topical drugs alone (on TA solution arm),Laser with topical drugs combination (on TA solution arm),Laser alone (on TA cream arm),Topical drugs alone (on TA cream arm),
Sponsors
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Thai descendant 2. Have healthy skin, i.e., the skin on the forearm is free of inflammation, infection, and dyspigmentation. 3. Patients who voluntarily agree to participate in the study
Exclusion criteria
Exclusion criteria: 1. Being pregnant, breastfeeding, or after giving birth for no more than 3 months 2. Have open wounds, scars, infections or tattoos on the forearm 3. Perform any skin treatment (e.g., tanning, laser) on the forearm within 4 weeks prior to the start of the study. 4. Have a history of allergy to steroids 5. Have photosensitive rash or sensitivity to light 6. Have a history of using substances that affect wound healing, such as using steroids or smoking regularly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of TA cream/solution in the stripped stratum corneum Immediate after treatment Measure using Ultra-High-Performance Liquid Chromatography | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events Immediate, 2 weeks after procedure Clinical evaluation | — |
Countries
Thailand
Contacts
Public ContactThrit Hutachoke
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed