Colorectal cancer increased incidences in Thailand annually, which was most commonly diagnosed in the advanced stage while less than 50% was diagnosed in stages I and II. Colonoscopy was considered a standard and common-used method for the screening, diagnosis, and treatment of disease today. Chronic constipation would affect cleansing during bowel preparation. In a foreign study, the preparation of the large intestine in people with constipation showed that the Split-dose of polyethylene glycol
Conditions
Interventions
split-dose PEG-ELS combination with Lubiprostone 3 times by specifying as follows
2 days before colonoscopy 1 capsule of Lubiprostone at 6.00 a.m. then took 1 capsule of Lubiprostone at 6 p.m. Day before colonoscopy - 1 capsule of Lubiprostone at 6.00 a.m. The subjects would recei
Active Comparator Drug,Placebo Comparator Drug
split-dose PEG-ELS combination with Lubiprostone 3 times ,split-dose PEG-ELS combination
Sponsors
Dr. Kawin Tangvoraphonkchai
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 18-75 years of age patients that are indicated for colonoscopy with constipation (Compatible with ROME IV diagnostic criteria for chronic constipation or history of Bristol stool form scale 1-2).
Exclusion criteria
Exclusion criteria: Suspected bowel obstruction or perforation, uncontrolled condition e.g. congestive heart failure, unstable angina pectoris, unstable hypertension, cardiac arrhythmia, liver failure, acute kidney injury, uncontrolled blood glucose, hypo-hyperthyroid state, cannot stop warfarin for 3 days, cannot stop antiplatelet for 7 days, history of colectomy, pregnancy or breastfeeding, history of drug allergy for PEG-ELS or Lubiprostone, coagulopathy(INR > 1.5), and thrombocytopenia (< 50000 /ul).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Ottawa bowel preparation score Colonoscopy day proportion of adequate bowel cleansing | — |
Secondary
| Measure | Time frame |
|---|---|
| adenoma detection rate Colonoscopy day Number of adenoma,safety profiles Colonoscopy day symptoms,satisfaction Colonoscopy day a questionnaire to assess the satisfaction | — |
Countries
Thailand
Contacts
Public ContactKawin Tangvoraphonkchai
Srinagarind Hospital Khonkaen University
Outcome results
None listed