The efficacy of aloe-vera gel with 10% urea cream on HFS compared with 10% urea-cream alone as the primary end point. Hand Foot Syndrome, Aloe vera, Capecitabine, DLQI
Conditions
Interventions
Add aloe vera gel in combination with 10% urea cream applied per hands and feet,10% urea cream applied per hands and feet as standard of care
Active Comparator Drug,Active Comparator Drug
aloe vera gel in combination with 10% urea cream ,10% urea cream
Sponsors
Navamindradhiraj University Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. patients at least 18 years of age. 2. patients diagnosed with cancers whose treatment need to be with capecitabine, either single capecitabine or with combination. 3. patients had never received capecitabine before randomization. 4. patients voluntarily not using other products except for 10% urea cream and/or aloe vera gel for hand and feet.
Exclusion criteria
Exclusion criteria: 1.Patients with history of allergic to aloe vera gel or urea cream were not eligible. Patients with widespread skin condition such as diffuse systemic sclerosis, erythrodermic psoriasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy At least 3 weeks of first dose capecitabine CTCAE grade | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life At least 3 weeks of first dose capecitabine Edit Remove DLQI score | — |
Countries
Thailand
Contacts
Public ContactLucksika Wanichtanom
Falculty of Medicine, Vajira hospital,Navamindradhiraj University
Outcome results
None listed