Basal bolus insulin therapy in critically ill patients: A randomized controlled trial.

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230410009

Enrollment

168

Registered

2023-04-10

Start date

2023-04-11

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically ill patients who will be admitted to medical intensive care unit and have capillary blood glucose within 180- 400 mg/dl. basal bolus insulin, critically ill patient, hyperglycemia

Interventions

1. Discontinue oral or injecting antidiabetic drugs on admission. 2. Start total daily insulin dose 0.4 unitsper kg per day when the admission blood glucose concentration is more than 180 mg per dL 3

Experimental Drug,No Intervention Drug

Basal bolus insulin,Sliding scale insulin

Eligibility

Sex/Gender

All

Age

18 Years to 120 Years

Inclusion criteria

Inclusion criteria: 1. Adult age more than 18 years olds and 2. capillary blood glucose in between 180 - 400 mg/dl.

Exclusion criteria

Exclusion criteria: 1) Patients need intravenous infusion insulin therapy 2) Continuous enteral feeding 3) Patients in a shock state with vasopressor and nothing per oral 4) Patient with Raynaud phenomenon, which interferes with capillary blood glucose measurement 5) Hypoglycemia prior admission 6) Chronic liver disease (child-pugh score B and C) 7) History of insulin allergy or anaphylaxis 8) Surgical patients 9) Known pregnancy 10) Patient who cannot consent form or identify LAR within 48 hr

Design outcomes

Primary

Measure	Time frame
Capillary blood glucose in 140-180 mg per dL 28 days or until discharge from ICU Mean	—

Secondary

Measure	Time frame
Mean daily CBG during study 28 days or until discharge from ICU Point of care test blood sugar,Glucose variability 28 days or until discharge from ICU Point of care test blood sugar,28 days overall mortality 28 days or until discharge from ICU Data from EMR or telephone interview,ICU length of stay 28 days or until discharge from ICU Data from EMR or telephone interview,Nosocomial infection 28 days or until discharge from ICU Data from EMR,Ventilator free day in 28 days 28 days or until discharge from ICU Data from EMR,Hypoglycemia less than 70 mg per dl 28 days or until discharge from ICU Point of care test blood sugar	—

Measure

Time frame

Mean daily CBG during study 28 days or until discharge from ICU Point of care test blood sugar,Glucose variability 28 days or until discharge from ICU Point of care test blood sugar,28 days overall mortality 28 days or until discharge from ICU Data from EMR or telephone interview,ICU length of stay 28 days or until discharge from ICU Data from EMR or telephone interview,Nosocomial infection 28 days or until discharge from ICU Data from EMR,Ventilator free day in 28 days 28 days or until discharge from ICU Data from EMR,Hypoglycemia less than 70 mg per dl 28 days or until discharge from ICU Point of care test blood sugar

—

Countries

Thailand

Contacts

Public ContactSupatida Turnsaket

Khon Kaen University

supatida.tu@kkumail.com0956050404

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026