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Comparison of efficacy between Conjugated equine estrogen and Nonsteroidal anti- inflammatory drug in treatment of abnormal uterine bleeding among hormonal subdermal implant users: A Randomized Controlled Trial

Comparison of efficacy between Conjugated equine estrogen and Nonsteroidal anti- inflammatory drug in treatment of abnormal uterine bleeding among hormonal subdermal implant users: A Randomized Controlled Trial

Status
Unknown
Phases
Phase 1Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230410002
Enrollment
64
Registered
2023-04-10
Start date
2022-06-13
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Management of abnormal uterine bleeding among hormonal subdermal implant users. Abnormal uterine bleeding Hormonal subdermal implant Conjugated equine estrogen Nonsteroidal anti-inflammatory drugs

Interventions

Conjugated equine estrogens one capsule (0.625 mg/capsule) two times a day for 5 days,Mefenamic acid two capsules (250 mg/ capsule) three times a day for 5 days
Experimental Drug,Experimental Drug
Conjugated equine estrogens ,Mefenamic acid

Sponsors

Khonkean hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Non pregnant women age 15 years old or older with using Single rod 68 mg Etonogestrel inserted 3 to 36 months before enrollment for contraception dysmenorrhea and complaints abnormal uterine bleeding

Exclusion criteria

Exclusion criteria: 1. Gynecological or medical diseases is cause abnormal uterine bleeding 2. Contraindicationorallergytoestrogenornonsteroidalanti-inflammatorydrugs 3. Chronicuseofnonsteroidalanti-inflammatorydrugs(morethantwotabletsthreetimesa week)

Design outcomes

Primary

MeasureTime frame
The duration of abnormal uterine bleeding among hormonal subdermal implant users was stopped after using of Conjugated equine estrogen and Nonsteroidal anti- inflammatory drug Duration of bleeding was stopped Calculated by Two independence means

Secondary

MeasureTime frame
The percentage of women who stopped bleeding within 7 days after initiation of treatment Less than 7 Days to stop bleeding Percentage (%),the adverse effects of using Conjugated equine estrogen and Nonsteroidal anti- inflammatory drug When person have adverse effect Number of person

Countries

Thailand

Contacts

Public ContactSalinee Polyota

Khon kean hospital

S.polyota@gmail.com0942637263

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026