Continuous intradialytic amino acid infusion is higher change of albumin level than loading dose of amino acid at 3 months Intradialytic parenteral nutrition Amino acid supplementation Intravenous infusion End-stage kidney disease Hemodialysis
Conditions
Interventions
The continuous group received infusion of 50% glucose 100 ml (200 kcal) followed by intravenous AAs 200 ml (14.4 g, 57.6
kcal) throughout session.,The loading group received rapid administration of 5
Experimental Other,Experimental Other
continuous intradialytic infusion,loading dose
Sponsors
Faculty of Medicine, Chulalongkorn University
Chongkonlneenithi Foundation
Eligibility
Sex/Gender
All
Age
18 Years to 98 Years
Inclusion criteria
Inclusion criteria: Adult patients (greater than or equal to 18 years old) Hemodialysis (greater than or equal to 3 months) Serum Alb 3.5 to 3.9 g/dL 7-points SGA A or Malnutrition inflammation score A or B
Exclusion criteria
Exclusion criteria: Allergy to Amino acid supplement Pregnancy or breastfeeding Metastatic cancer Ongoing infection On anti inflammatory drugs Cirrhosis HIV infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference of serum albumin at the beginning and next three month at 3 months after end of the intervention Colorimetric(Bromocresal green) | — |
Secondary
| Measure | Time frame |
|---|---|
| amino acid in serum and dialysate fluid at the first-used dialyzer Liquid chromatography mass spectrometry,Muscle mass at 3 months after end of the intervention Body Composition Monitor (BCM),muscle strength at 3 months after end of the intervention handheld dynamometer ,complications during three months of the intervention NA,serum albumin change at 3 months after end of the intervention Colorimetric(Bromocresal green) | — |
Countries
Thailand
Contacts
Public ContactSophon Dumrongsukit
Division of Internal Medicine-Nephrology Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital
Outcome results
None listed