A Randomized Clinical Trial Comparing the Success Rate of Pleurodesis with Thoracoscopic Talc Poudrage Combined with Indwelling Pleural Catheter versus Thoracoscopic Talc Poudrage in Patient with Malignant Pleural Effusion

Comparing the Success Rate of Pleurodesis with Thoracoscopic Talc Poudrage Combined with Indwelling Pleural Catheter versus Thoracoscopic Talc Poudrage in Patient with Malignant Pleural Effusion, A Randomized, Non-inferiority Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230312001

Enrollment

Registered

2023-03-12

Start date

2022-02-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant pleural effusion Malignant pleural effusion Thoracoscopic talc poudrage Indwelling pleural tunnel catheter Pleurodesis success

Interventions

Standard medical thoracoscope with talc pleurodesis (talc poudage),Standard medical thoracoscope with talc pleurodesis (talc poudage) followed by indwelling pleural tunnel catheter insertion

Placebo Comparator Procedure/Surgery,Active Comparator Procedure/Surgery

Thoracoscopic talc poudage (TTP),Thoracoscopic talc poudage plus indwelling pleural tunnel catheter insertion (TTP+IPC)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient with symptomatic malignant pleural effusion Age over 18 years old LENT score less than 5 ECOG score 0-2

Exclusion criteria

Exclusion criteria: Pregnancy Allergy to medication and talc Bleeding tendency Hemodynamic instability Recent myocardial infarction in 6 weeks Unexpandable lung, complicated pleural effusion

Design outcomes

Primary

Measure	Time frame
Pleurodesis success rate 12 weeks percent	—

Secondary

Measure	Time frame
Dyspnea score 1,6,12 weeks Visual analogue score ,Quality of life 12 weeks Questionnaire QoL 5D5L,Complication 1,6,12 weeks percent	—

Countries

Thailand

Contacts

Public Contactvorawut thanthitaweewat

Faculty of Medicine, Chulalongkorn University

kashikoi55@gmail.com0897638538

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026