Evaluation on the acute cutaneous tolerance of hair tonic from herbal extract, firming essence from emblica fruit, facial serum from sappan wood extract, and Herbal Enriched Cream

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230310003

Enrollment

Registered

2023-03-10

Start date

2023-01-17

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Thai volunteers aged between 20-50 years old Patch test, irritation test, skin irritation

Interventions

Cosmetic products: Hair tonic from herbal extract (Code: HT), Firming essence from emblica fruit extract (Code: FE), Facial serum from sappan wood extract (Code: FS) and Herbal Enriched Cream (Code: E

Experimental Other

Skin irritation of 4 cosmetic products

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Healthy male and female volunteers of all skin types with an age range of 20 - 50 years old. 2. Free of any wound, scar, or visible skin disease on the lower forearm area. 3. Willing to participate in the study after being informed on objective, methodology, possible risk and effect of the study. 4. Be able to read, communicate and write in Thai. 5. Willing to sign consent of the volunteer.

Exclusion criteria

Exclusion criteria: 1. History of hyperallergic reaction 2. History of allergy to any cosmetic products 3. History of allergy to Phyllanthus emblica , Zingiber officinale, Caesalpinia sappan, Garcinia celebica and other products containing these herbs 4. History of eczema or psoriasis within 6 months before the study 5. History of medical treatment with steroids, antibiotics, NSAIDs, anti-histamine within 3 days before the study 6. History of using topical tretinoin, benzoyl peroxide, corticosteroids, hydroquinone or other photosensitivity substances on the lower forearm area within 3 weeks before the study 7. Having any disease that requires regular topical treatment on the lower forearm area 8. History of major operation within 1 year 9. History of skin cancer within 1 year 10. Heavy smoker or regular alcoholic drinker 11. Pregnancy or lactation 12. History of addiction to any narcotic substances

Design outcomes

Primary

Measure	Time frame
Skin irritation and safety of cosmetic products 24 hours patch test	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactNeti Waranuch

Cosmetics and natural products research center, Pharmaceutical sciences, Naresuan university, Thailand

cosnat@nu.ac.th055968801

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026