Refractive error (Corneal disorders after trans-epithelial photorefractive keratectomy) Amnion, Photorefractive keratectomy, Wound healing, Refractive surgical procedures
Conditions
Interventions
The case group was treated with AMEED (Lifecell Pharmaceuticals, Inc. Iran) and artificial tear drop (Iranian Parenteral &
Pharmaceutical Co. Iran) every four hours (conventional treatment with AMEED) up to three days post-surgery.
It should be noted that both groups of patients have received routine and standard treatme
Pharmaceutical Co. Iran) (conventional treatment) was instilled every four hours within the same duration.
It should be noted that both groups of patients have received routine and standard treatment
Experimental Drug,Placebo Comparator No treatment
Corneal epithelial repair by Amniotic membrane extracted eye drop after trans-PRK,Corneal epithelial repair without Amniotic membrane extracted eye drop after trans-PRK
Sponsors
Nanobiotechnology Research Center of Baqiyatallah university
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Age 20-50 years old 2. Patients with refractive problems whose Range of spherical equivalent is between -5 to -1.5
Exclusion criteria
Exclusion criteria: 1. History of using topical ophthalmic drugs in the past three months 2. Any history of eye surgery 3. Use of drugs that affect the tear profile (such as: blood pressure medication, rheumatism medication, anti-psychotic medication, etc.) 4. History of any eye diseases other than refractive disorders 5. Patients with diabetes history 6. Patients with drug allergy 7. History of any systemic diseases especially rheumatologic disease 8. Patients with anisometric eyes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| size of corneal epithelial defects daily in both groups until the complete epithelial healing The patients' eyes are stained with fluorescein, and a photo of the stained part is taken with a photo slit device. The size of the defect in the picture will be determined by ImageJ software. | — |
Secondary
| Measure | Time frame |
|---|---|
| the corneal haziness 1st, 3rd, 6th months after surgery in both group measured the corneal haziness according to the standard evaluation ,pain measurement First, second and third day after surgery in both group The pain measurement was based on a 0-10 Likert scale.,conjunctival injection grading First, second and third day after surgery in both group using the Efron system,visual acuity 1st, 3rd, 6th months after surgery in both group using the Snellen chart | — |
Countries
Iran
Contacts
Public ContactAlireza Ranaei
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
Outcome results
None listed