The efficacy of intra-operative parecoxib with paracetamol for reducing opioid consumption in patient undergoing breast cancer surgery under general anesthesia breast cancer surgery, parecoxib, paracetamol
Conditions
Interventions
Parecoxib is an injectable parenteral prodrug of valdecoxib(selective COX-2 inhibitors), resulting in reduced production of prostaglandins, the substance that is involved in inflammation.4,5
Parecoxib
Active Comparator Drug,Placebo Comparator No treatment
Parecoxib combine with paracetamol intravenous,placebo( NSS)
Sponsors
FACULTY OF MEDICINE RESEARCH GRANT KHON KAEN UNIVERSITY
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: female age 18-65 year ASA classification 1-3 Patients scheduled for elective breast surgery under general anesthesia at operating room, Srinagarind hospital
Exclusion criteria
Exclusion criteria: Patients with hypersensitivity or contraindication to the study drugs. allergy for sulfamethoxazole History of opioid or steroid (Dexamethasone,Hydrocortisone) used. Pregnancy Psychologic problems Operation change Refuse to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative opioid consumption 24 hours measure opioid consumption (mg) | — |
Secondary
| Measure | Time frame |
|---|---|
| Post operative pain score 24 hour, 3 month numeric rating scale 0-10,assess quality of life during postoperatively 24 hour WHOQOL-BREF-THAI,side effect of opioid (Nausea and vomiting episode, ambulation, sedation score, RS depression) 24 hour grading score | — |
Countries
Thailand
Contacts
Public ContactThipphawan chanasuek
Faculty of Medicine, Khon Kaen University
Outcome results
None listed