Comparison of effectiveness between autologous Platelet-rich plasma and autologous fat with Platelet-rich fibrin in injection laryngoplasty for patients with unilateral vocal fold paralysis

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230227001

Enrollment

Registered

2023-02-27

Start date

2023-02-16

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with unilateral vocal fold paralysis unilateral vocal fold paralysis, injection laryngoplasty ,Platelet-rich plasma, Fat, Platelet-rich fibrin

Interventions

The Platelet-rich plasma (PRP) was made by taking 10-20 ml of peripheral blood from patient. Blood is then inserted to tube and centrifuge with 1500 rpm for 10 min then the PRP was extracted under ste

s abdomen to create the filler ( Fat with PRF ) for injection laryngoplasty under general anesthesia in operating room

Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery

autologous Platelet-rich plasma,autologous fat with Platelet-rich fibrin

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Unilateral vocal fold paralysis patients with 6 months onset is considered to injection laryngoplasty for treatment 2.Willing to give consent

Exclusion criteria

Exclusion criteria: 1.Age < 18 years 2.Patients with bleeding tendency or coagulopathy. 3.Patient isn't able to follow up as research protocol. 4.Patients received phonosurgery before. 5.Organic lesions were found, e.g., vocal polyps, vocal tumor, vocal cyst,or glottic cancer. 6.Patients with cricoarytenoid joint fixation or fibrosis at posterior vocal cord. 7.Patients who don't have enough fat for harvestment. 8.Patients who refuse to enroll the study

Design outcomes

Primary

Measure	Time frame
Voice handicap index (VHI) preoperative, postoperative at 1 month and 6 month Questionnaire of VHI score	—

Secondary

Measure	Time frame
Jitter preoperative, postoperative at 1 month and 6 month Dr.speech equipment,Shimmer preoperative, postoperative at 1 month and 6 month Dr.speech equipment,NHR preoperative, postoperative at 1 month and 6 month Dr.speech equipment,MPT preoperative, postoperative at 1 month and 6 month Dr.speech equipment	—

Countries

Thailand

Contacts

Public ContactVanusanan Sudsamai

Faculty of Medicine Ramathibodi Hospital, Mahidol University

Bo.vanusanan@gmail.com0948986249

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026