Children with pneumonia Vitamin D3, VitD3, calcidiol, 25[OH]D, cathelicidin, Interleukin-6, IL-6, Interleukin-8, IL-8, Interleukin-10, IL-10, pneumonia, children
Conditions
Interventions
Suplementation of Vitamin D 100.000 IU single dose by oral administration at first 3 days of admission in children ward of hospital.,Suplementation of placebo (glucose), single dose by oral administr
Experimental Drug,Placebo Comparator Drug
VItamin D3,Placebo
Sponsors
Internal Research of Airlangga University, Indonesia
Eligibility
Sex/Gender
Female
Age
1 Months to 60 Months
Inclusion criteria
Inclusion criteria: 1. Children aged 1 month- 5 years, 2. Diagnosed as pneumonia by a respirology pediatric consultant, 3. Had obtained permission from their family to participate to the study.
Exclusion criteria
Exclusion criteria: 1. Having taken vitamin D supplements 4 weeks before the study, 2. Children having received antibiotic more than 3 days before the study started, 3. Children with cyanotic congenital heart disease, kidney failure, and acute post-streptococcal glomerulonephritis, 4. A history of allergy to vitamin D.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Calcidiol (25[OH]D) level before intervention and 7 days after intervention ELISA test,IL-6 before intervention and 7 days after intervention ELISA test,IL-8 before intervention and 7 days after intervention ELISA test,IL-10 before intervention and 7 days after intervention ELISA test,Severity of pneumonia in children before intervention and 7 days after intervention PRESS score | — |
Secondary
| Measure | Time frame |
|---|---|
| nutritional status before intervention and 7 days after intervention WHO growth chart,Hemoglobin first admission in hospital routine laboratory examination,Leukocyte first admission in hospital routine laboratory examination,Calcium before intervention and 7 days after intervention routine laboratory examination,CRP first admission in hospital routine laboratory examination | — |
Countries
Indonesia
Contacts
Public ContactRetno Setyoningrum
Dr. Soetomo Hospital, SUrabaya, Indonesia
Outcome results
None listed