The Effect of Sodium Chloride Rinsing on Soft Tissue Healing of Extraction Wound: Pilot Study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230222004

Enrollment

Registered

2023-02-22

Start date

2022-02-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Patients who had bilaterally symmetrical non-infected premolars needed for extraction such as extraction for orthodontic treatment 2. Age between 15 to 35 years old 3. Patients who had American Society of Anesthesiologist (ASA) class I or II 4. No antibiotic usage extraction wound, soft tissue healing, 0.9% sodium chloride solution

Interventions

Sterile water rinse 2 times a day keep in the mouth for 2 minutes ,Normal saline solution rinse 2 times a day keep in the mouth for 2 minutes,1.8% Sodium Chloride solution rinse 2 times a day keep in

Placebo Comparator Biological/Vaccine,Active Comparator Biological/Vaccine,Active Comparator Biological/Vaccine

0% Sodium Chloride solution,0.9% Sodium Chloride solution,1.8% Sodium Chloride solution

Eligibility

Sex/Gender

All

Age

15 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria 1. Patients who had bilaterally symmetrical non-infected premolars needed for extraction such as extraction for orthodontic treatment 2. Age between 15 to 35 years old 3. Patients who had American Society of Anesthesiologist (ASA) class I or II 4. No antibiotic usage 5. Simple/atraumatic extraction

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. Infection is found at the site of extraction 2. Smokers or alcoholics 3. On drug therapy which may affect wound healing such as glucocorticoid steroids and non-steroidal anti-inflammatory drugs and oral contraceptive 4. Pregnant woman, lactating woman and patients who take estrogen-containing contraceptive drugs 5. Patients who have blood disorders like thalassemia, G6PD deficiency, sickle cell disease and hemochromatosis 6. Psychiatric patients 7. Patients who cannot participate with the study and post-operative follow-up

Design outcomes

Primary

Measure	Time frame
decrease in socket size and depth 1 week, 3 week millimeters	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactWalailak Kunteekanjana

Faculty of dentistry, Chulalongkorn University

6370025632@student.chula.ac.th0815859338

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026