Pain from endometrial biopsy by using manual vacuum aspiration abnormal uterine bleeding manual vacuum aspiration pain endometrial biopsy
Conditions
Interventions
NAPROXEN tablet 250 mg
oral route
preparation in capsule,Paracetamol tablet 500 mg
oral route
preparation in capsule,Placebo, Corn starch filled capsule
Naproxen,Paracetamol,Placebo
Sponsors
Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University
Eligibility
Sex/Gender
Female
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.) A non-pregnant woman who has abnormal bleeding from uterus, age between 30 - 70 years old, with one of following criteria a. Age >/= 45 years b. Age < 45 years with unopposed estrogen exposure or chronic anovulation c. Persistent abnormal uterine bleeding 3.) Not an anti-platelet or anti-coagulant agents user 4.) Adequate communication with Thai 5.) Consented to join the trial
Exclusion criteria
Exclusion criteria: 1. A woman who has had Paracetamol or NSAIDs agents within 24 hours before 2. A woman who has a history of allergy to NSAIDs or Paracetamol 3. A woman who has any contraindications in Naproxen using, such as peptic ulcer, asthma, bleeding disorder, and impaired renal or hepatic function; GFR < 30mL/min/1.73m2 4. A woman who has any contraindications in Paracetamol using, such as impaired liver function; AST >100 U/L or ALT > 100U/L), and alcoholism. 5. A woman who cannot understand the Visual Analogue Scale (VAS) 6. Participants who need to withdraw from the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain level immediately after the procedure finished and 10 minutes after the procedure Visual Analogue Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactKritakarn Telapol
Panyananthaphikkhu Chonprathan Medical Center
Outcome results
None listed