Muscle pain Long pepper extract Piper retrofractum Vahl muscle pain topical product piperine Deplee
Conditions
Interventions
Topical product containing 2% of Long pepper extract with 0.5% of menthol. The final product was composed of piperine 0.29 % w/w, as determined by a HPLC method.,The placebo was a gel preparation cont
Experimental Drug,Placebo Comparator Drug
2%Long pepper extract,Placebo
Sponsors
National Research Council of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Male or female with aged 18 years or older who had muscle pain confirmed by physician.
Exclusion criteria
Exclusion criteria: 1. Patients who experienced any clinically significant or unstable medical conditions. 2. Patients who were pregnant and childbearing. 3. Patients with a muscle pain due to systemic infection or patients with skin conditions such as wound or infection on pain area. 4. Patients who had known allergies to piperine, long pepper extract or other ingredients of products. 5. Patients who used oral or topical medicines for pain relief such as NSAIDS, methyl salicylate, steroids, opioids, tricyclic antidepressant, anticonvulsant within 1 week before starting date.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of improving present pain intensity (PPI) end of study Improvement in PPI was defined as no pain or decrease of present pain intensity (PPI) measured using Th-SFMPQ by at least 2 levels from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| proportion of treatment success in VAS end of study Treatment success defined as at least 80% reduction of visual analogue scale (VAS) at the end of the study compared with the baseline,improvement in verbal rating scale (VRS) in pain relief end of study VAS improvement defined as no pain or pain relief by at least 2 levels at the end of study compared with baseline.,average and percentage of VAS reduction end of study VAS score measured using the Thai-McGill questionnaire,average of pain scores on affective, sensory, and total score reduction end of study average reduction of pain score using the Thai-McGill questionnaire,patient satisfaction end of study average score,Number of paracetamols used end of the study Average number of paracetamols,Adverse event end of study number of adverse event | — |
Countries
Thailand
Contacts
Public ContactArchawin Rojanawiwat
Department of Medical Sciences, Ministry of Public Health
Outcome results
None listed