Treatment of post-acne erythema with a 589 nm Solid-state Laser Versus placebo cream in Asians: A Split Face, Single-blinded, Randomized Controlled Trial

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230217005

Enrollment

Registered

2023-02-17

Start date

2023-02-27

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The healthy patient between 18 to 50 years old who have no active acne or mild to moderate bilateral facial inflammatory acne with bilateral post-acne erythema Post acne erythema

Interventions

Patients underwent six treatment sessions at 2-week intervals. Each patient received one pass with the 589 nm laser treatment on post acne erythema lesions only to the randomized treatment side of th

Experimental Device,Sham Comparator Drug

Laser side,aloe vera cream

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Healthy males and females between 18 to 50 years old 2. Patients who have no active acne or mild to moderate bilateral facial inflammatory acne with bilateral post-acne erythema 3. Fitzpatrick skin Types III to V

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating woman 2. Patients who had received oral vitamin A derivatives in the past 3 months 3. Patients receiving facial laser treatments within the past 1 months 4. Patients with history of photosensitive disease 5.Patients with any medical condition that might affect acne and wound healing process 6.Patients with skin infection or history of skin cancer 7.Patients who withdrew from the study

Design outcomes

Primary

Measure	Time frame
Compare improvement of post-acne erythema between solid state 589 nm laser versus placebo cream (aloe vera) in the treatment of post-acne erythema at 2,4,6,8,10,12,14,18 weeks after the begin of intervention Investigator global assessment scale, Visit camera, Antera 3D skin analysis, 10 point clinical assessment score	—

Secondary

Measure	Time frame
1.patient satisfaction after treatment post acne erythema between solid state 589 nm laser versus placebo cream(aloe vera) 2.side effect from solid state 589nm laser patient record side effect at 0,2,4,6,8,10,12,14,18 weeks and pain score assessment at 0,2,4,6,8,10 weeks and patient satisfaction score at 10,12,14,18 weeks after the begin of intervention patient record side effect ,10 point pain score assessment , 10 point patient satisfaction score	—

Measure

Time frame

1.patient satisfaction after treatment post acne erythema between solid state 589 nm laser versus placebo cream(aloe vera) 2.side effect from solid state 589nm laser patient record side effect at 0,2,4,6,8,10,12,14,18 weeks and pain score assessment at 0,2,4,6,8,10 weeks and patient satisfaction score at 10,12,14,18 weeks after the begin of intervention patient record side effect ,10 point pain score assessment , 10 point patient satisfaction score

—

Countries

Thailand

Contacts

Public ContactWarittha Maitrisathit

Faculty of Medicine Ramathibodi Hospital,Mahidol University

Waritthanannie@gmail.com0815564252

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026