Effect of Two Low Doses of Dexmedetomidine on Anesthetic Consumptions with Propofol-Based Anesthesia during Intracranial Neurosurgery

Effect of Two Low Doses of Dexmedetomidine on Anesthetic Consumptions with Propofol-Based Anesthesia during Intracranial Neurosurgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230214001

Enrollment

132

Registered

2023-02-14

Start date

2023-03-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurosurgical conditions which are required to undergo elective intracranial surgery elective craniotomy, Dexmedetomidine propofol-based anesthesia

Interventions

16 mL of 0.9% NaCl solution, intravenous infusion 4 mL/h for 4 hours ,DEX in 16 mL of 0.9% NaCl solution concentration based on the patient body weight divided by 20, so infusion rate of 4 mL/h is equ

Placebo Comparator Drug,Experimental Drug,Experimental Drug

Control,DEX 0.2 ,DEX 0.4

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who are scheduled for elective craniotomy from March 1, 2023 to February 28, 2026 1. Age 18 - 65 years old 2. American Society of Anesthesiologists (ASA) 1-3 3. Glasgow Coma Scale (GCS) 14, 15

Exclusion criteria

Exclusion criteria: 1. Second- or third-degree atrioventricular (AV) block 2. Baseline heart rate (HR) less than 60/min 3. Ventricular dysfunction 4. Hepatic impairment 5. Chronic kidney disease (CKD) stage > 4 6. Pregnancy 7. Morbid obesity 8. On medication with alpha -methyldopa, clonidine 9. Need intraoperative neuromonitoring (IONM), which no need for neuromuscular blockade 10. Currently receive more than 2 kinds of antiepileptic drugs

Design outcomes

Primary

Measure	Time frame
Intraoperative consumptions of propofol and fentanyl during 4 hours of the operation milligram of propofol and microgram of fentanyl consumption	—

Secondary

Measure	Time frame
hemodynamic parameters before, during, and after study drug infusion mmHg, beat per minute	—

Countries

Thailand

Contacts

Public ContactAnanchanok Saringcarinkul

Faculty of Medicine, Change Mai University

asaringc@yahoo.com66946296109

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026