Patients who are scheduled for elective craniotomy from March 1, 2023 to February 28, 2026 elective craniotomy
Conditions
Interventions
16 mL of 0.9% NaCl solution, intravenous infusion 4 mL/h for 4 hours ,DEX in 16 mL of 0.9% NaCl solution concentration based on the patient body weight divided by 20, so infusion rate of 4 mL/h is equ
Control,DEX 0.2 ,DEX 0.4
Sponsors
Faculty of Medicine, Change Mai University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: elective craniotomy, ASA I-III, GCS 14-15
Exclusion criteria
Exclusion criteria: 1. Second- or third-degree atrioventricular (AV) block 2. Baseline heart rate (HR) less than 60/min 3. Ventricular dysfunction 4. Hepatic impairment 5. Chronic kidney disease (CKD) stage > 4 6. Pregnancy 7. Morbid obesity 8. On medication with alpha -methyldopa, clonidine 9. Need intraoperative neuromonitoring (IONM), which no need for neuromuscular blockade 10. Currently receive more than 2 kinds of antiepileptic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative consumptions of propofol and fentanyl during 4 hours of the operation milligram of propofol and microgram of fentanyl consumption | — |
Secondary
| Measure | Time frame |
|---|---|
| hemodynamic parameters during 4 hours of operation mmHg, beat per minute | — |
Countries
Thailand
Contacts
Public ContactAnanchanok Saringcarinkul
Faculty of Medicine, Change Mai University
Outcome results
None listed