Improvement of uremic toxin clearance by novel hemodialysis modalityes and equipment can improve clinical outcome and survival of chronic dialysis patients. middle cut off dialyzer inflammatory cytokine clearance online hemodiafiltration
Conditions
Interventions
Convetional thrice weekly hemodialysis with middle cutoff dialyzer which proved efficacy of middle and large molecule uremic toxin removal for 8 weeks,Thrice weekly online Hemodiafiltration for 8 week
Experimental Device,Active Comparator Device
Hemodialysis with middle cutoff dialyzer,online hemodialysis
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Thrice weekly chronic hemodialysis more than 3 months Hemodialysis via arteriovenous fistula or graft Adequate hemodialysis define as spKt/V > 1.2 per session
Exclusion criteria
Exclusion criteria: Pregnancy Vascular access dysfunction Advanced staged of cancer Advanced staged of cardiovascular disease Life expectancy less than 1 year Previous severe infection and/or hospitalization within 3 months Previous history of severe anaphylaxis from dialyzer reaction Currently recieved immunosuppressive drug Currently received online hemodiafiltration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inflammatory cytokine clearance 8 weeks (pre-post hemodialysis inflammatory cytokine level)*100/pre dialysis inflammatory cytokine level | — |
Secondary
| Measure | Time frame |
|---|---|
| Intradialytic albumin loss 8 week (pre-post hemodialysis albumin level)*100/pre hemodialysis albumin level ,intradialytic complication 8 weeks rate of intradialytic hypo/hypertension,Dialyzer reaction 8 weeks Rate of dialyzer reaction intrahemodialysis | — |
Countries
Thailand
Contacts
Public ContactHansa Kidkaem
Faculty of Medicine, Khon Kaen University
Outcome results
None listed