1. Portal hypertension in the absence of overt parenchymal chronic liver disease has been described in small cohorts of patients with human immunodeficiency virus (HIV) with complications including variceal bleeding and ascites. 2. Spleen stiffness measurements (SSM) have shown a superior association with the presence of portal hypertension compared with LSM in cirrhosis patients. HIV Infections Idiopathic Noncirrhotic Portal Hypertension
Conditions
Interventions
Group 1.1: HIV infected patients with prior DDI exposure
Group 1.2: HIV infected patients without prior DDI exposure,sex and age matched Healthy subject
Diagnostic,Diagnostic
HIV infected patients ,Healthy subject
Sponsors
Department of Internal Medicine, Phramongkutklao Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: HIV-infected patients aged more than 18 years and currently on ARV
Exclusion criteria
Exclusion criteria: Chronic viral hepatitis Cirrhosis Active infective or opportunistic illness, malignancy, Pregnancy Cardiac failure Significant liver disease due to any cause Alcohol consumption in excess of current recommended limits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spleen stiffness measurements at the study period Point shearwave elastography | — |
Secondary
| Measure | Time frame |
|---|---|
| liver stiffness measurements at the study period Point shearwave elastography | — |
Countries
Thailand
Contacts
Public ContactSakkarin Chirapongsathorn
Phramongkutklao Hospital and College of Medicine
Outcome results
None listed