Lichen planus pigmentosus Lichen planus pigmentosus Platelet-rich plasma Pigmentation Melanin
Conditions
Interventions
PRP will be prepared according to the manufacturer'
s instructions.
PRP will be injected intradermally into LPP lesions, with 0.1 mL per each injection, 1 cm apart
Experimental Procedure/Surgery
Platelet-rich plasma treatment
Sponsors
Institute of dermatology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients who were diagnosed with lichen planus pigmentosus, age 18 - 60 years 2. Has facial LPP lesion for at least 6 months 3. Histology confirmed LPP as evidenced by perivascular infiltrate, lichenoid reaction, melanophages and pigment pigmentation (melanin) accumulates under the epidermis and dermis. 4. Patch test result is negative
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant or breastfeeding 2. Patients with a history of keloids, hypertrophic scars, herpes virus infection or skin disease around the lesion 3. Patients with blood disorders, liver disease or patients receiving chemotherapy/ anticoagulants 4. Patients with hyperpigmentation from other conditions, such as pigmented contact dermatitis, with positive patch test results, fixed drug eruption, lichenoid drug reaction, ochronosis, melasma, PIH, endocrinopathies, etc. 5. Patients with a history of treatment using topical bleaching agents and lasers within 6 months prior to study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quartile grading scale (QGS) 0,2,4,6,8,12 weeks quartile grading scale (QGS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction 0,2,4,6,8,12 weeks Patient satisfaction score | — |
Countries
Thailand
Contacts
Public ContactChanisa Kiatsurayanon
Institute of dermatology
Outcome results
None listed