The use of repetitive transcranial magnetic stimulation combined with home based exercise on motor and non motor symptoms in individuals with Parkinson disease

The effects of repetitive transcranial magnetic stimulation combined with home based exercise in individuals with Parkinson disease

Status

Unknown

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230127001

Enrollment

Registered

2023-01-27

Start date

2023-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The participant in this study is people with Parkinson disease. Brain stimulation, Gait performance, Parkinson disease, Home-base exercise

Interventions

rTMS combined with home-based exercise will be used to improve gait performance. The parameters will be used for stimulation (10 Hz. at sub-motor threshold).,rTMS in this group will be stimulated by t

s disease

Experimental Other,Sham Comparator Other,No Intervention Drug

real rTMS + Home based exercise,Sham rTMS + Home based exercise,Control group

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) clinically diagnosed with PD stages 2 to 3 as assessed by the modified Hoehn and Yahr scale 2) the age groups between 50 and 75 years 3) taking PD medication regularly for at least a month 4) able to use smart phone for download metronome application 5) able to walk independently without any assistive device 6) able to follow commands and instructions

Exclusion criteria

Exclusion criteria: 1.contraindication for TMS confirmed by TMS screening questionnaire 2.severe action or resting tremor 3. severe rigidity 4. ON/OFF medication fluctuations 5. severe disability from dyskinesia 6. Diagnosed with secondary parkinsonism 7. other neurological and/or musculoskeletal problems 8.implanted deep brain stimulation (DBS) or plan to have DBS during the study period

Design outcomes

Primary

Measure	Time frame
Gait performance and balance Pre, post 10 sessions of rTMS stimulation, and post 8 weeks Gait performance will be reflected several outcomes such as time-up-and go and functional reach test	—

Secondary

Measure	Time frame
Cortical outcomes Pre, post 10 sessions of rTMS stimulation, and post 8 weeks Cortical outcomes will be represented by corticomotor excitability (MEP) and cortical inhibition (CSP) that will be measured by a single-pulse TMS.	—

Countries

Thailand

Contacts

Public Contactfuengfha Khobkhun

Faculty of Physical Therapy, Mahidol University

fuengfa.kho@mahidol.ac.th024415450

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026