Oxygenation in Intra-abdominal pressure (IAP) guided positive end-expiratory pressure (PEEP) during general anesthesia in laparoscopic abdominal surgery with Trendelenburg positioning,A feasibility study

Acomparison between oxygenation in intra-abdominal pressure (IAP) guided positive end-expiratory pressure (PEEP) group and conventional PEEP group during general anesthesia ni laparoscopic abdominal surgery with Trendelenburg positioning, A feasibility study

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230126002

Enrollment

Registered

2023-01-26

Start date

2023-01-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing laparoscopic abdominal surgery with trendelenburg position. mechanical ventilation, perioperative care, positive end expiratory pressure, laparoscopic surgery

Interventions

After CO2 insufflation in abdomen, mechanical ventilation in intervention group will be set PEEP level guided be intraabdominal pressure until surgery ended. PEEP level is calculated from equation (0.

Experimental Procedure/Surgery,No Intervention No treatment

IAP guided PEEP ,Conventional

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adults age more than 18 years old, 2. Patients undergoing laparoscopic abdominal surgery with trendelenburg position

Exclusion criteria

Exclusion criteria: 1.Patients'refusal, 2.BMI > 30 kg/m2, 3.Lung bleb or bullae diagnosed by preoperative chest radiograph, 4.COPD , 5.Lung fibrosis, 6.pregnancy,7. end-stage renal disease , 8. Increased intracranial pressure , 9. circulatory shock during preoperative period, 10. pneumothorax during preoperative period

Design outcomes

Primary

Measure	Time frame
oxygenation 1 hour after intervention P/F ratio	—

Secondary

Measure	Time frame
lung compliance 1 hour after intervention dynamic lung compliance,oxygenation 30 minutes after intervention P/F ratio,Postoperative pulmonary complications 5 days after surgery Postoperative pulmonary complications,incidence of intraoperative complications 24 hour after intervention partial pressure of oxygen,pneumothorax,hypotension,incidence of recruitment maneuver during surgery number of times,hospital stay within 6 days after intervention days	—

Measure

Time frame

lung compliance 1 hour after intervention dynamic lung compliance,oxygenation 30 minutes after intervention P/F ratio,Postoperative pulmonary complications 5 days after surgery Postoperative pulmonary complications,incidence of intraoperative complications 24 hour after intervention partial pressure of oxygen,pneumothorax,hypotension,incidence of recruitment maneuver during surgery number of times,hospital stay within 6 days after intervention days

—

Countries

Thailand

Contacts

Public ContactSrisuluk Kacha

Faculty of Medicine Chiangmai University

srisuluk.ka@cmu.ac.th6653935522

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026