Non-infected acute diarrhea. Ya-dhat-ban-job, Ya-leung-pid-sa-mut, Andrographis paniculata, non-infected randomised-controlled trial, primary care
Conditions
Interventions
Ya-dhat-ban-job (The formula follows the national herbal drug list)
Dosage form: white capsule 500 mg
Dosage regimen: 2 capsules 3 times per day before meal (plus two placebo capsules before bedtime),
Experimental Other,Experimental Other,Experimental Other,Placebo Comparator Other
Ya-dhat-ban-job,Ya-leung-pid-sa-mut,Andrographis paniculata ,Placebo
Sponsors
Faculty of Pharmacy, Mahasarakham University
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with acute diarrhea who have a loose stool at least three times per day or a mucus stool at least one time per day or a watery stool at least one time per day. Patients may also have nausea or vomit predominantly. 2. Present with the following symptoms: slightly fatigued, regular pulse, normal blood pressure, no sunken eyes, and capillary refill time less than 2 seconds. 3. Age between 20-60 years old 4. No fever 5. No blood in stool 6. Consent to take part in the study
Exclusion criteria
Exclusion criteria: 1. Allergic to one of the three herbal formulas or the ingredients used in these formulas. 2. Previously received antibiotics or other medications for diarrhea. 3. Regularly taking anticoagulants or antiplatelets. 4. Being pregnant or planning to get pregnant at the time of the study. 5. Having one of these health conditions related to liver, renal, heart, diabetes, hypertension, and HIV. 6. Taking immunosuppressant. 7. Taking any medications which induce diarrhea, such as laxatives.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of bowel movement Before intervention and three days after the intervention (Day 0, 1, 2, 3) Frequency | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of vomit Before intervention and three days after the intervention (Day 0, 1, 2, 3) Frequency,Abdominal camps Before intervention and three days after the intervention (Day 0, 1, 2, 3) Pain visual analog scales,Fatigue Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the fatigue is recovered compare to yesterday.,Bowel movement Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the bowel movement is recovered compare to yesterday.,Abdominal cramps Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the abdominal is recovered compare to yesterday.,Nausea/Vomit Three days after the intervention (Day 1, 2, 3) Patient were interviewed if the nausea/vomit is recovered compare to yesterday.,Dehydration Three days after the intervention (Day 1, 2, 3) Patient were interviewed to assess dehydration whether it is recovered compare to yesterday. | — |
Countries
Thailand
Contacts
Public ContactManeeya Sangsawai
Faculty of Pharmacy, Mahasarakham University
Outcome results
None listed