Moderate to severe Acne Vulgaris in Thai female Acne Vulgaris
Conditions
Interventions
A double-blinded, randomized, controlled, split-face trial.
Patients were asked to apply Topical Niacinamide, Zinc and Magnesium 0.4ml on one half of the face. Combined with oral doxycycline (100mg)
Experimental Drug,Placebo Comparator Drug
Topical Niacinamide, Zinc and Magnesium,Placebo
Sponsors
Ornicha Perapapan
Eligibility
Sex/Gender
Female
Age
15 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1. Thai female age 15-25 years old 2. Moderate to severe Acne Vulgaris as IAA grading 3.No historical allergies to topical niacinamide or Zinc 4.No historical allergies to oral doxycycline 5. Patients have not to changes their cream or medications within 4 weeks prior to the study 6. Have not received oral retinoids 6 months prior to the study 7. Have not underwent comedone extraction, intralesional steroid, chemical peeling, laser resurfacing 1 month prior to the study, 8. No underlying diseases, such as polycystic ovarian syndrome, adrenal tumor 9. Not pregnant or breastfeeding
Exclusion criteria
Exclusion criteria: 1. Decline to participate 2. Severe drug allergy 3. Take others creammedicine during the study 4. Poor compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflamed acne At 7 days, 1,2,3 months Photograph, Lesion count | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-inflammatory hyperpigmentation At 1,2,3 months Mexameter,Sebum reduction At 1,2,3 months Sebumeter,C. acnes At 1,2,3 months Visiopor,New inflamed acne lesion At 7 days, 1,2,3 months Photograph, lesion count,Trans epidermal water loss At 1,2,3 months Corneometer | — |
Countries
Thailand
Contacts
Public ContactOrnicha Prapapan
Lion Suphannahong Medical Clinic
Outcome results
None listed