Major gastrointestinal surgery Dexmedetomidine, Propofol, Major gastrointestinal surgery, Intestinal barrier function, D-lactate, Randomized
Conditions
Interventions
Intravenous dexmedetomidine (4mcg/ml) 0.2-0.7 mcg/kg/hr for 24 hrs,Intravenous propofol(10mg/ml) 0.5-4 mg/kg/hr for 24 hrs
Experimental Drug,Experimental Drug
Dexmedetomidine,Propofol
Sponsors
Medicine faculty, King Chulalongkorn memorial hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age more than 18 years old and under 80 years old 2. Elective case for major GI surgery 3. Tracheal intubation and mechanical ventilation at least 12 hrs in ICU admission 4. Epidural Analgesia
Exclusion criteria
Exclusion criteria: 1. Pregnancy and breast feeding 2. Organ or bone marrow Transplants 3.Delirium or dementia 4.Cerebrovascular accident 5. High grade atrioventricular blocks without cardiac pacemaker 6. Acute liver failure 7.contraindications for epidural analgesia 8. Allergy to propofol or dexmedetomidine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D-lactate dehydrogenase 0,12,24 hrs at the beginning of study colorimetric | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first defecation at the beginning of study hours | — |
Countries
Thailand
Contacts
Public ContactJantarat Wisawachaiwat
Faculty of medicine, Chulalongkorn university
Outcome results
None listed