The participant in this study is people with Parkinson disease. Brain stimulation Bradykinesia Coordination Parkinson disease Reach-to-grasp performance
Conditions
Interventions
HF-rTMS is a non-invasive brain stimulation that will be used to enhance the activation over the supplementary motor area. The parameters will be used for stimulation (10 Hz. at sub-motor threshold).,
Experimental Other,Experimental Other,Experimental Other,Sham Comparator Other
HF-rTMS over the Supplementary motor area (SMA) group,HF-rTMS over the primary motor area (M1) group,Combination of HF-rTMS over the SMA and M1,Sham group
Sponsors
Research Grant for New Scholar supported by National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1 age range from 40 to 80 years 2 mild to moderate severity with Hoehn and Yahr H&Y stages 1 to 3 3 more impaired on the right hand dominant as examined by the Unified Parkinson Disease Rating Scale part III 4 On medication during practicing and testing in this study 5 ability to understand and follow simple commands with greater than 23 on the Mini mental state examination Thai version 2002 6 Have normal or corrected to normal vision and normal hearing and 7 ability to sit independently for more than one hour
Exclusion criteria
Exclusion criteria: 1.contraindication for TMS confirmed by TMS screening questionnaire 2.severe action or resting tremor 3. severe rigidity 4. ON/OFF medication fluctuations 5. severe disability from dyskinesia 6. Diagnosed with secondary parkinsonism 7. other neurological and/or musculoskeletal problems 8.implanted deep brain stimulation (DBS) or plan to have DBS during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral outcomes Baseline and post intervention The Behavioral outcomes will be represented by reach-to-grasp actions that will be measured by the motion monitor tracking systems. This will be showed by the kinematic data such as movement time(ms). | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortical outcomes Baseline and Post intervention Cortical outcomes will be represented by corticomotor excitability (MEP) and cortical inhibition (CSP) that will be measured by a single-pulse TMS. | — |
Countries
Thailand
Contacts
Public ContactJenjira Thanakamchokchai
Faculty of Physical Therapy, Mahidol University
Outcome results
None listed