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A pilot study and a randomized-controlled trial alongside cost-effectiveness analysis of the comparative efficacy between cannabidiol (CBD)-containing ointment and 50 mcg/g calcipotriol ointment and 0.1% triamcinolone cream in the treatment of plaque-type psoriasis

A pilot study and a randomized-controlled trial alongside cost-effectiveness analysis of the comparative efficacy between cannabidiol (CBD)-containing ointment and 50 mcg/g calcipotriol ointment and 0.1% triamcinolone cream in the treatment of plaque-type psoriasis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230117009
Enrollment
60
Registered
2023-01-17
Start date
2025-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild plaque-type psoriasis Marijuana, Cannabis, Cannabidiol, Calcipotriol, Triamcinolone, Plaque-type psoriasis, Cost

Interventions

CBD ointment of different concentrations will be used
Experimental Drug
CBD ointment

Sponsors

Institute of dermatology, Ministry of public health
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Male or female diagnosed with mild plaque-type psoriasis 2. Age 18-60 years 3. Otherwise healthy 4. Willing to participate and can come for scheduled follow-ups

Exclusion criteria

Exclusion criteria: 1. Have acute skin inflammation/infection which is not psoriasis 2. Have been treated with topical tar-containing products, vitamin A and vitamin D derivatives, corticosteroids, UVB phototherapy withinthe previous two weeks 3. Have been treated with oral vitamin A derivatives, corticosteroids, cyclosporine, methotrexate, PUVA phototherapy or laser therapy within the previous 4 weeks 4. Have been treated with immunosuppressants such as alefacept, etanercept, infliximab, efalizumab or adalimumab within the previous 12 weeks 5. Have other diseases or currently taking other drugs which may interfere with normal skin function and with this study such as beta-blocker, lithium, oral contraceptive pill, ACE inhibitor, antimalarial, NSAIDS, interferon, imiquimod, gemfibrozil 6. Have a history of allergy to cannabis/cannabis products, steroids, vitamin D derivatives 7. Pregnant of breast-feeding

Design outcomes

Primary

MeasureTime frame
Efficacy 2 months ESI/IGA score

Secondary

MeasureTime frame
cost-effectiveness 2 month cost-effectiveness analysis

Countries

Thailand

Contacts

Public ContactChanisa Kiatsurayanon

Institute of dermatology

chanisa.kiatsurayanon@gmail.com0917182555

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026