Acquired bilateral nevus of Ota-like macule platelet rich plasma Nevus Nevus of Hori Acquired bilateral nevus of Ota-like macule
Conditions
Interventions
PRP was injected into both lesional facial areas of each patient four times, at intervals of every two weeks (week 0, 2, 4, 6 of the study). Each session includes the following steps.
1. The blood wi
Active Comparator Drug
Intradermal platelet-rich plasma injection
Sponsors
Institute of Dermatology
Eligibility
Sex/Gender
All
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients between the ages of 25 and 65 with bilateral Hori's nevus
Exclusion criteria
Exclusion criteria: 1. Pregnancy and breastfeeding 2. History of PRP allergy 3. History of bleeding disorder such as thalassemia or thrombocytopenia 4. History of blood-borne disease include hepatitis B, hepatitis C or HIV 5. Patient who currently on anti-oxidant supplement such as vitamin C, vitamin E within 3 months prior. 6. Patient who got chemotherapy and anti-coagulant within three months prior to the study 7. Patient who had done LASER or IPL within three months prior to the study 8. Patient who concomitant use of whitening agents, chemical peeling within three months prior to the study 9. Patient who significantly had co-existing hyperpigmented lesion except Hori's nevus 10. Patient who has any active skin disease on the PRP injected area such as infection, skin cancer, dermatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hori nevus area and severity baseline (week 0 of the study) and the two-week, four-week, eight-week, and twelve-week post-treatment follow-ups (week 8, 10, 14 and 18 of the study) Modified derml pigmentation area and severity index | — |
Secondary
| Measure | Time frame |
|---|---|
| Melanin measurements baseline (week 0 of the study) and the two-week, four-week, eight-week, and twelve-week post-treatment follow-ups (week 8, 10, 14 and 18 of the study) Melanin index,Brightening of the lesion the two-week, four-week, eight-week, and twelve-week post-treatment follow-ups (week 8, 10, 14 and 18 of the study) Brightening score,Patients satisfaction the two-week, four-week, eight-week, and twelve-week post-treatment follow-ups (week 8, 10, 14 and 18 of the study) Patients satisfaction score,Side effect On each session, short-term side effect will be collected on day 1 and day 3 post-tx. long-term side effect will be collected at the 2-wk, 4-wk, 8-wk, and 12-wk post-tx followup Pain score, edema score, erythema(yes or no), hyperpigmentation (yes or no), infection ( yes or no), transient ischemia (yes or no), bruise (yes or no), papules (yes or no), pustules (yes or no) | — |
Countries
Thailand
Contacts
Public ContactPasinee Deeudomwongsa
Institute of Dermatology
Outcome results
None listed