Effectiveness of 0.5% Cannabidiol in Alcohol Solution versus Alcohol Solution on Skin Barrier Function: Crossover Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230110001

Enrollment

Registered

2023-01-10

Start date

2023-06-14

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

general population who use alcohol solution in daily life Alcohol Cannabidiol TEWL

Interventions

Topically apply 0.5% cannabidiol in 70% alcohol solution on both hands at least 10 times per day (3 mL per time) for 2 weeks. And, participants are not allowed to use other alcohol preparation or hand

Active Comparator Drug,Placebo Comparator Drug

0.5% cannabidiol in 70% alcohol solution, 70% alcohol solution

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) 18-65 years of age in both sex (2) Use 0.5% cannabidiol in alcohol solution or alcohol solution at least 2 times per day (3) No history of allergy to alcohol solution or cannabinoid (4) Will not use hand cream in 4 weeks of participation (5) Subjects must have been informed about all study procedures and side effects and informed consent must be given to all subjects (6) Able to speak, read, and understand Thai language

Exclusion criteria

Exclusion criteria: (1) Chronic skin diseases of hands (2) Pregnancy or lactation (3) Obsessive-Compulsive Disorder concerning over-washing hands Withdrawal criteria 1. Develop serious adverse side effects during the study 2. Develop a synchronous local infection at hand 3. Do not follow instructions 4. Lost follow up at any appointment 5. Decided to leave the study

Design outcomes

Primary

Measure	Time frame
Skin quality at 0 and 2 weeks after end of each intervention (Day0,14,16,30) Larson scale, Frosch and Kligman , transepidermal water loss, skin moisture	—

Secondary

Measure	Time frame
Adverse side effects at 2 weeks after end of each intervention (Day 14,30) erythema, pruritus, burning, stinging, scaling, other ranging from no, mild, moderate to severe,Participant satisfaction at 2 weeks after end of each intervention (Day 14,30) Color, Smell, Sticky feeling, Irritation, Skin dryness, Ease of use, Speed of drying , Pleasant feeling ranging from 1 to 7	—

Countries

Thailand

Contacts

Public ContactThanida Manitchotpisit

Chulabhorn international college of medicine Thammasat university

wowthanida@gmail.com66896130555

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026