Effect of vitamin D supplement on muscle function, metabolic markers and quality of life in post I-131 hypothyroid patients

Effect of vitamin D supplement on muscle function, metabolic markers and quality of life in post I-131 hypothyroid patients : A randomized placebo-controlled trial

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20230107005

Enrollment

Registered

2023-01-07

Start date

2023-01-11

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitamin D supplement on muscle function in hypothyroid patients vitamin D supplement on metabolic markers in hypothyroid patients vitamin D supplement on quality of life in hypothyroid patients vitamin D hypothyroidism muscle function metabolic markers quality of life

Interventions

Physical examination by measuring height, weight, blood pressure, waist circumference, body composition, hand grip strength, 5-times chair stand test, and quality of life questionnaires measured using

Active Comparator Drug,Placebo Comparator Drug

Ergocalciferol(20,000IU),Placebo

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients with I-131 induced hypothyroidism and currently receiving thyroid hormone therapy with normal thyroid hormone levels and stable thyroid hormone replacement doses for at least 6 months 2. 18 to 70 years of age

Exclusion criteria

Exclusion criteria: 1. Patients with thyroid cancer 2. Patients with underlying disease such as cerebrovascular disease, chronic kidney failure(eGFR < 60 ml/min/1.73m2), diabetes mellitus, muscle disease, major depressive disorder, cancer, liver cirrhosis (Child-Pugh class B,C) , and malabsorption 3. Patients with abnormal calcium and phosphate levels 4. Pregnant patient 5. Patient who was already receiving vitamin D and calcium supplements

Design outcomes

Primary

Measure	Time frame
Hand grip before the study, in the 3rd month, and in the 6th month Jamar handgrip dynamometer,5 times chair stand test before the study, in the 3rd month, and in the 6th month Time used(sec)	—

Secondary

Measure	Time frame
Lean body mass(kg) before the study, in the 3rd month, and in the 6th month Tanita BC-545 N body composition analyzer ,Fat mass(kg) before the study, in the 3rd month, and in the 6th month Tanita BC-545 N body composition analyzer,Insulin resistance before the study, in the 3rd month, and in the 6th month By using HOMA-IR,Quality of life before the study, in the 3rd month, and in the 6th month By answering questionnaires SF-36	—

Measure

Time frame

Lean body mass(kg) before the study, in the 3rd month, and in the 6th month Tanita BC-545 N body composition analyzer ,Fat mass(kg) before the study, in the 3rd month, and in the 6th month Tanita BC-545 N body composition analyzer,Insulin resistance before the study, in the 3rd month, and in the 6th month By using HOMA-IR,Quality of life before the study, in the 3rd month, and in the 6th month By answering questionnaires SF-36

—

Countries

Thailand

Contacts

Public ContactSureephan Maneewan

Faculty of Medicine, Chiang Mai University

poomsuree163@gmail.com053935482

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026