chronic hemodialysis locking solution citrate permanent catheter hemodialysis
Conditions
Interventions
30 percent trisodium citrate as the locking solution for tunneled-cuffed catheter for hemodialysis in end-stage kidney disease patients in every post-dialysis setting and whenever needed for 1 year.,h
Experimental Drug,Active Comparator Drug
trisodium citrate,heparin
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Chronic hemodialysis patients via tunneled-cuffed catheter 2. Newly inserted tunneled-cuffed catheter for hemodialysis at right internal jugular vein 3. Age more than 18 years
Exclusion criteria
Exclusion criteria: 1. Patients that refuse to give consent 2. Previously diagnosis of heparin induced thrombocytopenia 3. Severe liver impairment 4. Patients on cardiac pacemaker or with uncontrolled cardiac arrhythmia 5. Serum calcium less than 8.4 mg/dl within 2 months before enrollment 6. Patients currently on systemic anticoagulant 7. History of allergy to heparin or trisodium citrate 8. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRBSI 1 year events per catheter-days,catheter dusfunction 1 year events per catheter-days | — |
Secondary
| Measure | Time frame |
|---|---|
| exit-site infection 1 year events per catheter-days,tunnel infection 1 year events per catheter-days,catheter removal 1 year time to event,mortality 1 year rate,cost-effectiveness 1 year cost utility analysis | — |
Countries
Thailand
Contacts
Public ContactThawee Chanchairujira
Siriraj hospital, Mahidol University
Outcome results
None listed