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A randomized controlled trial on the use of Nitrous oxide versus conventional intravenous pain relief in minor gynecological procedures

A randomized controlled trial on the use of Nitrous oxide versus conventional intravenous pain relief in minor gynecological procedures

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20230107003
Enrollment
138
Registered
2023-01-07
Start date
2021-08-25
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

analgesic efficacy of the patient controlled inhaled Nitrous oxide with intravenous opioids (Pethidine &amp

Interventions

the participants were instructed to begin inhalation Nitrous oxide via mouthpiece 2 minutes before start procedure and continue inhaling gas when she felt pain or until end of procedure. If the partic
Experimental Drug,Active Comparator Drug
Nitrous oxide group,Pethidine group

Sponsors

Endowment fund, Faculty of Medicine, Chiang Mai University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Female, 18 years of age or older 2. Treat with dilatation and curettage, fractional curettage and MVA 3. Able to self-controlled inhaled Nitrous oxide 4. Volunteer to participate

Exclusion criteria

Exclusion criteria: 1. hemodynamic unstable 2. contraindication for Nitrous oxide or Pethidine/Midazolam such as history of severe respiratory or cardiac disease, thyroid disease, neurological disorder, renal disorder 3. upper respiratory infections or sinus blockage, recent history of middle or inner ear surgery, pneumothorax or intestinal obstruction 4. ASA physical status III/IV 5. history of curettage

Design outcomes

Primary

MeasureTime frame
Pain score during procedure, immediately post-procedure, 30-mins post-procedure Numerical Rating Scale

Secondary

MeasureTime frame
satisfactory level, side effects, discharge time post-procedure questionnaire interview

Countries

Thailand

Contacts

Public ContactNapas Lohtrakul

Faculty of Medicine, Chiang Mai University

napas.lohtrakul@hotmail.com0860014216

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026