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Comparing intraoperative opioid consumption in patients who received preemptive oral paracetamol versus no preemptive oral paracetamol in elective cranial surgery.

Comparing intraoperative opioid consumption in patients who received preemptive oral paracetamol versus no preemptive oral paracetamol in elective cranial surgery.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20230105001
Enrollment
336
Registered
2023-01-05
Start date
2023-01-05
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preemptive analgesia as oral paracetamol and intraoperative opioid consumption in elective cranial surgery Preemptive analgesia oral paracetamol intraoperative opioid consumption cranial surgery elective surgery

Interventions

Patients who received Preemptive oral paracetamol before surgery.,Patients who didn&#039
t receive Preemptive oral paracetamol before surgery.
Treatment,Treatment
Preemptive oral paracetamol,No preemptive oral paracetamol

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Elective cranial surgery patients including craniotomy and craniectomy surgery 2. Age 18-90 years 3. ASA class I-III

Exclusion criteria

Exclusion criteria: 1. Emergency surgery 2. Awake craniotomy 3. Age less than 18 years 4. Use of intraoperative IV paracetamol without preemptive oral paracetamol 5. Use of intraoperative IV lidocaine 6. Use of IV opioid infusion intraoperatively 7. Use of preoperative pain medications 8. Cranial biopsy 9. Transsphenoidal surgery 10. Cranioplasty surgery 11. Pregnant Patients

Design outcomes

Primary

MeasureTime frame
intraoperative opioid consumption including induction till end of surgery fentanyl mcg per hr—

Secondary

MeasureTime frame
hemodynamic changes at intubation at intubation SBP, DBP and heart rate—

Countries

Thailand

Contacts

Public ContactSuraj Kafley

Department of Anesthesiology

kafleyfamily@gmail.com074451651

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026