Efficacy of methoxyflurane inhaler to analgesia during genicular nerve block in osteoarthritis knee; a randomized control trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20221231003

Enrollment

Registered

2022-12-31

Start date

2023-01-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

35-85 year-old patients with osteoarthritis knee (Kellgren-Lawrence grade 3-4) who had intractable pain more than 3 months and failure to conservative treatments. methoxyflurane, osteoarthritis knee, genicular nerve block

Interventions

Methoxyflurane Inhaler with local anesthesia,local anesthesia

Experimental Drug,No Intervention Drug

M group,L group

Eligibility

Sex/Gender

All

Age

35 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age 35-85 years old 2. Severe OA knee (KL III-IV) with chronic knee pain > 3 mo. 3. Failure to conservative treatments including physical therapy and non-opioid analgesics 4. Ability to use methoxyflurane inhaler

Exclusion criteria

Exclusion criteria: 1. Refusal patients 2. BW < 45 kg 3. Allergy to any study medication (fluorinated anesthetics, lidocaine, steroid) 4. Personal or family history of malignant hyperthermia 5. Cardiorespiratory disease e.g. arrhythmia, ischemic heart disease, chronic lung disease 6. Hepatic/renal dysfunction 7. Seizure disorder 8. Uncontrolled bleeding disorder 9. Poorly controlled psychiatric condition including active substance use disorder and personality disorder 10. Un-cooperated patients

Design outcomes

Primary

Measure	Time frame
pain score during genicular nerve block a 0-10 verbal numerical rating scale	—

Secondary

Measure	Time frame
Anxiety level post genicular nerve block Thai State-Trait Anxiety Inventory from Y-1,Maximal sedation level during vehicular nerve block Pasero Opioid-Induced Sedation Scale (POSS),Adverse events e.g. hypertension, tachycardia, desaturation and dizziness during geniular nerve block Number of patients,functional limitation and satisfaction 1-month follow-up Patient Global Impression of Improvement,Behavioral pain during genicular nerve block Critical care pain observational tool	—

Measure

Time frame

Anxiety level post genicular nerve block Thai State-Trait Anxiety Inventory from Y-1,Maximal sedation level during vehicular nerve block Pasero Opioid-Induced Sedation Scale (POSS),Adverse events e.g. hypertension, tachycardia, desaturation and dizziness during geniular nerve block Number of patients,functional limitation and satisfaction 1-month follow-up Patient Global Impression of Improvement,Behavioral pain during genicular nerve block Critical care pain observational tool

—

Countries

Thailand

Contacts

Public ContactNuj Tontitisin

Department of Anesthesiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University

nuj.ton@mahidol.ac.th022011513

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026