elderly osteoarthritis patients Bilateral total knee arthroplasty , combined periarticular tranexamic acid and intravenous tranexamic, intravenous tranexamic
Conditions
Interventions
Intravenous Tranexemic acid alone IV (1g) + periarticular injection normal saline ( 40ml) in Simultaneous Bilateral Total Knee Arthroplasty, Intravenous Tranexemic acid alone IV (1g) + periarticular
Intravenous Tranexemic acid alone IV(1g)+ periarticular injection normal saline( 40ml) in Simultaneous Bilateral Total Knee Arthroplasty, Combine intravenous Tranexemic acid IV (1g) with periarticul
Sponsors
Charoenkrung Pracharak Hospital
Eligibility
Sex/Gender
All
Age
56 Years to 90 Years
Inclusion criteria
Inclusion criteria: Severe osteoarthritis stage 3-4 both legs
Exclusion criteria
Exclusion criteria: 1. Ischemic heart disease on antiplatelet drug 2. contraceptive pill 3. Pulmonary embolism 4. MI 5. Stroke 6. TIA 7. Coagulation defect 8. Allergy of tranexamic acid 9. Anemia (Hb < 11g/dL) 10. BMI >30 11.Serum creatinine > 1.35 mg/10 ml
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood volume loss calculated from Hb day 0 and 3 3 day after intervention ml | — |
Secondary
| Measure | Time frame |
|---|---|
| Deep vein thrombosis and infection 3 months after intervention number | — |
Countries
Thailand
Contacts
Public ContactPete Chalongviriyalert
Medical Service Department
Outcome results
None listed