healthy volunteers glycemic index, postprandial glucose, medical food
Conditions
Interventions
Subjects are asked to drink 50g glucose solution (2 measurements on 2 separate days) within 12-15 minutes.
Blood is drawn at baseline and 15,30,45,60,90 and 120 minutes to measure changes in plasma g
50g glucose solution (2 measurements),medical food using whole milk plus rice ,medical food lactose-free milk plus rice
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. age 18 years and older 2. fasting plasma glucose < 100mg/dL 3. no prior history of diabetes and no prior treatment with glucose-lowering drugs 4. no history of food allergy 5. participants taking aspirin, birth control pills, vitamins and supplements, anti-hypertensive drugs, osteoporosis drugs at stable doses for 1 month or more are eligible for study inclusion
Exclusion criteria
Exclusion criteria: 1. significant medical problems requiring ongoing treatment, including but not limited to cancer, cardiac, pulmonary, hepatic, brain diseases or severe infection within 1 year before study inclusion 2. surgery or hospital admission within 3 months before study inclusion 3. history of allergy to medical food and lactose (or one or more of its components) used in the current study 4. pregnancy and lactation 5. use of thyroid hormones 6. history of diabetes or previous use of glucose-lowering drugs or insulin 7. diagnosis of diseases which significantly affect food digestion and absorption such as inflammatory bowel disease, Crohn's disease, ulcerative colitis 8. treatment with medications which can affect blood glucose levels, such as steroids, protease inhibitors, and antipsychotic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycemic index, postprandial glucose area under the curve (AUC) 0-120min glycemic index equals (glucose AUC from medical food) / (glucose AUC from 50g glucose ) | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin response, insulin AUC 0-120 min Insulin response, insulin AUC | — |
Countries
Thailand
Contacts
Public ContactPornpoj Pramyothin
Mahidol University
Outcome results
None listed