The study conducts in healthy volunteers who have either deep mesioangulation or horizontal impacted teeth which will cause loss of alveolar bone support after surgical removal of the teeth. The bone graft materials will be put inside the tooth sockets in order to prevent the loss of alveolar bone support as aforementioned. Autogenous tooth substitute graft Xenogeneic bone graft Impacted teeth Alveolar bone loss Alveolar preservation
Conditions
Interventions
1.Usual surgical removal of the 3rd molar in both experimental site and control site by using the same flap design and surgical removal technique.
2.The tooth will be completely cleaned off any soft t
Experimental Biological/Vaccine,Active Comparator Other
Autogenous tooth substitute graft ,Xenogeneic bone graft
Sponsors
Mahidol University
Eligibility
Sex/Gender
All
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1.Male or female aged between 20-30 years old 2.Bilateral mesioangulated or horizontal impacted mandibular 3rd molars with present 2nd molars 3.No pathological lesion involved with both the mandibular 2nd and 3rd molars and surrounding bones 4.Co-operative and able to follow the instructions
Exclusion criteria
Exclusion criteria: 1.Patients with systemic disease or medical conditions that may impair the wound healing process 2.Patients with existing active infection at either site of mandibular 3rd molars 3.Patients with generalized periodontal disease 4.Patients with smoking habit 5.Patients with orthodontic appliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tooth mobility Pre-operation, 2 weeks post-operation, 3 months post-operation, 6 months post-operation Miller Classification 1st Degree Tooth mobility less than 1 mm horizontally, 2nd Degree Tooth mobility more than1 mm horizontally, 3rd Degree Tooth mobility more than 1 mm with vertical mobility,Pain score Pre-operation, 2 weeks post-operation Numerical rating scale,Swelling score Pre-operation, 2 weeks post-operation The three facial lines were measured on pre-operation day and measure again on 2 weeks post-op. The percentages of increase in total facial measurements between two days were calculated. ,Nerve alteration Pre-operation, 2 weeks post-operation Any symptom of anesthesia, paresthesia or dysesthesia of the lower lip, chin, buccal gingiva, and tongue.,Presence of trismus Pre-operation, 2 weeks post-operation Measeure maximum mouth opening less than 35 mm considered as trismuss ,Presence of infection Pre-operation, 2 weeks post-operation Any symptom of purulent drainage, and any signs or symptoms of infection: pain or tenderness, localized swelling, redness, or warmth at surgical site,Soft tissue healing Pre-operation, 2 weeks post-operation Early soft tissue healing score,Mean grey value Pre-operation, 2 weeks post-operation, 3 months post-operation, 6 months post-operation The radiographic data will be digitized and saved in tag image file format. The ImageJ 2.1.0 software (GNU General Public License) will calculate the mean grey value of Region of interest (ROI),Fractal dimension Pre-operation, 2 weeks post-operation, 3 months post-operation, 6 months post-operation The radiographic data will be digitized and saved in tag image file format. The ImageJ 2.1.0 software (GNU General Public License) will calculate the fractal dimension of Region of interest (ROI),Grafted bone margin 6 months post-operation Radiolucent line between grafted material and bone scoring Score 0 Non-union, Score 1 Partial union, Score 2 Total union,Vertical bone dimension Pre- | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficiency of autogenous tooth substitute graft in reducing osseous defect after surgical removal of mandibular third molar 2 weeks post-operation, 3 months post-operation, 6 months post-operation Clinical and radiographic data in primary outcomes | — |
Countries
Thailand
Contacts
Public ContactDr. Phaichaya Laiamnuay
Faculty of Dentistry Mahidol University
Outcome results
None listed