Coronary artery disease patient coronary artery disease, coronary artery bypass graft, metabolomics study, transcriptomics study
Conditions
Interventions
Patients undergoing conventional CABG technique and receiving blood cardioplegia,Patients undergoing conventional CABG technique and receiving crystalloid cardioplegia,Patients undergoing on-pump beat
conventional CABG with blood cardioplegia,conventional CABG with crystalloid cardioplegia,on pump beating heart CABG,off pump CABG
Sponsors
Faculty of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Coronary artery disease patients that indicated for CABG surgery 2. Can perform informed consent patient 3. Age more than 18 years
Exclusion criteria
Exclusion criteria: 1. Requiring concomitant procedure 2. Emergency surgery 3. all types of atrial fibrillation 4. Recent myocardial infarction not more than 2 weeks 5. Other underlying diseases including neurologic disorders, chronic renal failure requiring dialysis, liver disease, active cancer, or any other serious medical condition. 6. Absence of written informed consent 7. Recent infection (fever 38.0 C, c-reactive protein (CRP) more than 20 mg/L,) 8. Immune compromise including Anti-HIV, Hepatitis B or Hepatitis C infection, Treponema pallidum 9. Pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabolomics profile day 3 after surgery level of metabolite | — |
Secondary
| Measure | Time frame |
|---|---|
| transcriptomics profile day 3 after surgery RNA sequencing | — |
Countries
Thailand
Contacts
Public ContactChananya Karunasumetta
Faculty of Medicine, Khon kaen University
Outcome results
None listed