The patients who had concern of uneven skin tone, wrinkle, large pore, discoloration or dullness, and requirement of facial skin rejuvenation photoaging facial skin rejuvenation non-ablative laser
Conditions
Interventions
Each patient received one pass with the 589nm laser followed by one pass with the 1319 nm laser to the randomized side of the face (split face).,The control side was not treated (split face).
Experimental Device,No Intervention No treatment
lasered side,Control (untreated)
Sponsors
Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Healthy females aged 18 years old and above 3. The patients who had concern of uneven skin tone, wrinkle, large pore, discoloration or dullness, and requirement of facial skin rejuvenation 4. Patients who willing to participate in the study and follow the protocol with signing the consent form
Exclusion criteria
Exclusion criteria: 1. Patients who have severe systemic disease 2. Patients who have active acne lesions, facial skin infection or other facial skin disorder for example solar lentigo, melasma 3. Patients who had apply any types of topical medication at face past 1 month 4. Patients who had chemical peeling past 3 months 5. Patients who had been injected dermal filler, botulinum toxin or any other laser or rejuvenation procedures affect facial skin past 6 months 6. Patients who use oral isotretinoin past 6 months 7. Pregnant and lactating patients 8. Patients who disincline for participating in the study 9. Patients who withdraw from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin texture, skin tone, wrinkle, spot, pore size, pigmentation, and sebum secretion at 2,4,6,10,18 weeks after the beginning of intervention The modified Fitzpatrick wrinkle scale, 10-point clinical assessment score, 10-point satisfaction rating scale, UV reflectance photography using VISIA system, Antera 3D camera | — |
Secondary
| Measure | Time frame |
|---|---|
| histological change of in vivo human tissue, adverse effect pain score: 0,2,4,6 weeks after the beginning of intervention. skin biopsy: at 10 and 18 weeks after the beginning of intervention. adverse event report: every patient's visit Histological analysis by skin biopsy, pain score, adverse event report | — |
Countries
Thailand
Contacts
Public ContactSonphet Chirasuthat
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed