Patients with symptoms compatible with functional dyspepsia. Functional dyspepsia Omeprazole Curcumin Turmeric
Conditions
Interventions
Curcumin 250mg and Omeprazole 20mg,Curcumin 250mg and Placebo of Omeprazole 20mg,Placebo of Curcumin 250mg and Omeprazole 20mg
Curcumin and Omeprazole (C+O),Curcumin and Placebo of Omeprazole (C),Placebo of Curcumin and Omeprazole (O)
Sponsors
Ministry of Public Health, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Symptoms compatible with functional dyspepsia, 2.Age between 18 and 70 years, 3.ECOG performance status 0 or 1, 4.Not taken aspirin or NSAIDs for the past 3 months, 5.Not taken curcumin or food that significantly contained curcumin during 4 weeks before the study, 6.No symptoms of irritable bowel syndrome (constipation, diarrhea, and frequent defecation), 7.Not taken herbal medication or medication that can affect gastrointestinal symptoms and diseases, 8.Not taking PPIs during the 4 weeks before the study.
Exclusion criteria
Exclusion criteria: Patients who were pregnant/breastfeeding; had a curcumin allergy; had gallstones; had ulcers or lumps in their stomach, duodenum, or esophagus; had severe inflammation of the gastric mucosa oesophageal mucosa or intestinal mucosa; had been infected with gastric Helicobacter pylori; had diseases that would hinder the treatment of functional dyspepsia, or had symptoms or physical signs that are a warning sign of serious diseases incompatible with functional dyspepsia, were excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Short-Form Leeds Dyspepsia Questionnaire Day0, Day28, and Day56 Frequency and severity of dyspepsia symptoms,Severity of Dyspepsia Assessment Day0, Day28, and Day56 Severity of Dyspepsia for randomized clinical trials | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events Day 28 Proportion | — |
Countries
Thailand
Contacts
Public ContactPradermchai Kongkam
Chulalongkorn University
Outcome results
None listed