Chronic mild to moderate pain in late-stage gonarthrosis late-stage knee osteoarthritis, paracetamol, placebo, numerical rating scale, modified WOMAC score, adverse events
Conditions
Interventions
500 mg of Acetaminophen three times a day orally,The placebos look like Acetaminophen
Experimental Drug,Placebo Comparator Drug
Acetaminophen,Placebo
Sponsors
Navamindradhiraj university
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Late stage primary knee osteoarthritis 50-75 years old with Chronic mild to moderate knee pain with Kellgren-Lawrence III-IV
Exclusion criteria
Exclusion criteria: Patients with non-ambulatory status; secondary knee osteoarthritis; severe pain or acute flare-up osteoarthritis; allergy to paracetamol or naproxen or omeprazole; preexisting routine consumption of other analgesic drugs; active hepatic disease with significant transaminitis; chronic renal disease with eGFR less than 30 mL/min/1.73m2; psychiatric disease needed treatment; history of gastritis or upper gastrointestinal bleeding; and other conditions using hepatotoxic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain control 2, 6, 12 weeks Numeric rating scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional outcome 2, 6, 12 weeks Thai version of modified WOMAC score,Depression 2, 6,12 weeks Thai geriatric depression score-15,Liver function test 2, 6,12 weeks Total bilirubin, AST, ALT,Rescue drug 2, 6, 12 weeks Number of Naproxen use,Patient satisfaction 12 weeks Satisfied or Unsatisfied,Renal function test 2, 6, 12 weeks Creatinine and eGFR | — |
Countries
Thailand
Contacts
Public ContactWaewwan Peungsomboonying
Faculty of Medicine Vajira Hospital, Navamindradhiraj university, Thailand
Outcome results
None listed