Urine electrolyte to predict treatment response in syndrome of inappropriate antidiuretic hormone

Urine electrolyte to predict treatment failure of fluid restriction in syndrome of inappropriate antidiuretic hormone

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20221206001

Enrollment

Registered

2022-12-06

Start date

2022-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Syndrome of inappropriate antidiuretic hormone Syndrome of inappropriate antidiuretic hormone, predictor , Fluid restriction, Urine electrolyte, urine-to-serum electrolyte ratio

Interventions

A patient with hyponatremia from SIADH that not respond to fluid restriction.,A patient with hyponatremia from SIADH that respond to fluid restriction.

Other,Other

Non responder,Responder

Eligibility

Sex/Gender

All

Age

15 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Hyponatremia patients from SIADH 2. Age more than 15 years old 3. Treated with fluid restriction < 800 ml/day (include fluid from parenteral and enteral intake)

Exclusion criteria

Exclusion criteria: 1. Patients who recieved Chronic diuretic therapy 2. Cannot collect urine sample per study protocol 3. Hemodynamic instability 4. Severe symptomatic hyponatremia 5. Severe hyperglycemia define as blood sugar > 300 mg/dL 6. Cannot take food orally

Design outcomes

Primary

Measure	Time frame
sensitivity and specificity of Urine-serum electrolyte ratio 4 days and 7 days after fluid restriction therapy percent	—

Secondary

Measure	Time frame
sensitivity and specificity of Urine sodium 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of Urine osmole 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of serum urea 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of Urine output 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of FeUric 4 days and 7 days after fluid restriction therapy percent	—

Measure

Time frame

sensitivity and specificity of Urine sodium 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of Urine osmole 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of serum urea 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of Urine output 4 days and 7 days after fluid restriction therapy percent,sensitivity and specificity of FeUric 4 days and 7 days after fluid restriction therapy percent

—

Countries

Thailand

Contacts

Public ContactKittiphan chienwichai

Hatyai hospital

ble_sama@hotmail.com0945946458

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026