Effect of Letrozole co-stimulation with gonadotropin in women with normal ovarian reserve on oocyte maturation: a Randomized controlled trial

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20221125002

Enrollment

144

Registered

2022-11-25

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertile women age 18-40 years Letrozole co-stimulation normal ovarian reserve oocyte maturation FOI GDF-9 BMP-15

Interventions

Letrozole co stimulation with gonadotropin Letrozole 5 mg oral OD (until the day before trigger ovulation) r-FSH 150 IU sc OD (start from cycle day 1 to 3 until the day before trigger ovulation) GnRH

Experimental Drug,Experimental Drug

Letrozole co stimulation with gonadotropin,Conventional ovarian stimulation

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile women aged 18 to 40 years BMI 18.5-29.9 kg/m2 AMH 1.2-7 ng/ml AFC 5 or more Basal FSH < 10 IU/L Basal E2 < 80 pg/ml

Exclusion criteria

Exclusion criteria: PCOS Endometriotic cyst Hypogonadotropic hypogonadism

Design outcomes

Primary

Measure	Time frame
Number of MII After oocyte incubation 2 hours and oocyte denuation Gardner system	—

Secondary

Measure	Time frame
Follicle to oocyte index Within the day of oocyte pick up number of oocyte x 100 / AFC,GDF-9 and BMP 15 protein within one year after oocyte pickup Indirect ELISA	—

Countries

Thailand

Contacts

Public ContactDaungporn Hunsawongsakul

Faculty of medicine, Siriraj hospital, Mahidol university

daungporn.ob@gmail.com0869040798

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026