Mixed type of melasma symmetrically distribute on both cheeks melasma microfocused ultrasound prevention recurrence relapse
Conditions
Interventions
Microfocused ultrasound (Ultherapy, Merz Aesthetics, Germany) with 1.5-mm transducer, energy 0.18J per pulse, 50 treatment lines
1064nm Q-switched Nd:YAG laser (Revlite, Cynosure, United States) 8m
Experimental Device,Experimental Device
Microfocused ultrasound and low fluence Q switched Nd:YAG laser,Low fluence Q switched Nd:YAG laser alone
Sponsors
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Mixed type of melasma on both cheeks 2. Can participate the follow up visit
Exclusion criteria
Exclusion criteria: 1. Having active infection on treatment area 2. Having open wound on treatment area 3. Having any of serious medical or dermatologic conditions including autoimmune disorders, scars, or severe cystic acne on the face, a history of skin cancer, a history of photosensitive disorders, or allergy to topical anesthesia 4. Having a previous history of taking oral contraceptive pills or hormone replacement within 1 year 5. Having a previous history of the following treatments or procedure for melasma including topical whitening agents within 1 month, oral or injected treatment within 3 months, laser treatment , dermabrasion, peeling, radiofrequency or focused ultrasound within 6 months 6. Having a history of filler injection on treatment area within 1 year 7. Having a previous history of metal implant on treatment area 8. Pregnancy or lactation 9. Withdraw from study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence of melasma at 57, 85, 113, 141, 169 days after the last treatment relative lightness index, melasma area and severity index | — |
Secondary
| Measure | Time frame |
|---|---|
| efficacy and safety of microfocused ultrasound at 57, 85, 113, 141, 169 days after the last treatment lightness index, melasma area and severity index, patient's report of adverse events | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed