The Effect of Root Canal Sealer on Postoperative Pain

The Effect of Calcium Silicate-Based and Calcium Hydroxide-Based Root Canal Sealer on Postoperative Pain: Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20221118004

Enrollment

Registered

2022-11-18

Start date

2022-10-26

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain arising after root canal treatment is undesirable but may manifest in hours and may persist for days following treatment. The incidence of post-endodontic pain has been reported to be between 3-58% with severe pain being observed at a rate of less than 12% of the entire population after treatment calcium silicate-based root canal sealer, calcium hydroxide-based root canal sealer, postoperative pain root canal treatment

Interventions

sealer is a part of root canal treatment. gutta percha seals with sealer and applied to the canal. in one group we used calcium silicate based endodontic sealer.,sealer is a part of root canal treatme

Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery

calcium silicate based endodontic sealer,calcium hydroxide based endodontic sealer

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Healthy persons between the ages of 18 and 60 years 2. Mandibular molar teeth that were diagnosed with symptomatic apical periodontitis 3. Patients with preoperative pain scores ranging from moderate to severe (45-100) on a visual analog scale (VAS).

Exclusion criteria

Exclusion criteria: 1. Patients who had taken analgesic or anti-inflammatory drugs within the last 12 hours 2. Pregnant or lactating patients 3. Patients having severe malocclusion associated with a traumatic occlusion 4. Teeth with severe damage 5. Teeth with calcified canals 6. Teeth with pain to percussion 7. Teeth with periapical radiolucency 8. Teeth with root resorption 9. Teeth with an immature/open apex 10. Teeth with previous RCT

Design outcomes

Primary

Measure	Time frame
postoperative pain at one week after end of the intervention visual analog scale	—

Secondary

Measure	Time frame
analgesic intake at one week after end of the intervention analgesic intake any of time	—

Countries

Turkey

Contacts

Public Contactmine buker

Faculty of Dentistry, mersin university

dishek@mersin.edu.tr05512151766

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026