Palliative care of non-diabetic chronic kidney disease stage 5 who denied long-term renal replacement therapy Palliative care, end-stage kidney disease, denied renal replacement therapy
Conditions
Interventions
Oral Keto amino acid tablet dose 600 mg/ 5 Kg of ideal body weight/day with a very low protein diet (VLPD) providing 0.3 g dietary protein/Kg ideal body weight/day with energy intake of 30 -35 kcal/kg
Experimental Drug,No Intervention No treatment
Keto amino acid and very low protein diet,Low protein diet
Sponsors
Clinical Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1. estimated GFR (CKD-EPI) < 6 mL/min/1.73 m2 without uremic symptoms 2. estimated GFR (CKD-EPI) over 6 - < 15 mL/min/1.73 m2 with uremic symptoms 3. denied receiving long-term renal replacement therapy by their wills
Exclusion criteria
Exclusion criteria: 1. acute life-threatening disease 2. urine protein excretion greater than 3 g/d, liver failure 3. human immunodeficiency virus infection 4. previous episodes of cardiac failure, 5. diabetes mellitus 6. active malignancies other than basal cell carcinoma 7. chronic obstructive pulmonary diseases requiring supplementary oxygen 8. a significant disorder of amino acid metabolism, e.g. hereditary diseases. 9. Participation in an interventional clinical trial during the last 2 months before individual enrolment of the patient 10. known allergic reactions to the active ingredients or constituents of the pharmaceutical preparation 11. pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life, effect of kidney disease every 2 months for 6 months sub score of KDQOL | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic profile and blood chemistries every 2 months for 6 months Electrolyte, CBC, Ca, Phosphate level, Lipid profile,Inflammatory markers every 2 months for 6 months interleukin-6, CRP,Nutritional assessment every 2 months for 6 months SGA score, albumin, prealbumin,Renal function every 2 months for 6 months eGFR,total score of KDQOL every 2 months for 6 months KDQOL score,Mortality rate every 2 months for 6 months time to event of dead with renal failure ,Rate and time to initial dialysis every 2 months for 6 months time to event | — |
Countries
Thailand
Contacts
Public ContactParamat Thimachai
Phramongkutklao hospital
Outcome results
None listed