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The prevalence of mutations in the MC4R, POMC and LEPR genes in Thai patients with morbid obesity receiving bariatric surgery and bariatric surgery outcome

The prevalence of mutations in the MC4R, POMC and LEPR genes in Thai patients with morbid obesity receiving bariatric surgery and bariatric surgery outcome

Status
Unknown
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20221109004
Enrollment
200
Registered
2022-11-09
Start date
2022-01-24
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Monogenic obesity Bariatric surgery Obesity Bariatric surgery Obesity genetics MC4R POMC LEPR Remission of diabetes

Interventions

Patients with MC4R, POMC, or LEPR mutation,Patients without MC4R, POMC, or LEPR mutation
Diagnostic,Diagnostic
Mutation carriers,Non-carriers

Sponsors

Ratchadapisek Somphot Fund
Lead Sponsor
Thai Red Cross Society Fund,The Thai Endocrine Society Research Grant (2022)
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Morbid obesity who underwent bariatric surgery 2.Age between 18 and 65 years

Exclusion criteria

Exclusion criteria: 1.Syndromic forms of obesity 2.Obesity due to endocrine disorders 3.Obesity due to hypothalamic disorders 4.Pregnancy and lactation 5.Weight loss lowering medications after surgery

Design outcomes

Primary

MeasureTime frame
Prevalence of mutations Time at enrollment Sanger sequencing—

Secondary

MeasureTime frame
Percentage of total weight loss Body weight after surgery at 3, 6, 12, 18 months and then yearly Body weight—

Countries

Thailand

Contacts

Public ContactPrimploy Greeviroj

Faculty of Medicine, Chulalongkorn University

primploy.greeviroj@hotmail.com0917142555

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026